SPRAVATO® Therapy at iMind
Now there is new hope for people living with depression.
- SPRAVATO® (esketamine) is the first and only prescription nasal spray for depression
- FDA approved for Treatment Resistant Depression (TRD) and Major Depressive Disorder (MDD) with suicidal ideation
- iMind is proud to be a SPRAVATO® REMS treatment center
- We are the first in Port St. Lucie, Florida, to offer this breakthrough treatment
What is SPRAVATO® (esketamine)?
SPRAVATO® is a purified form of ketamine, treatments effect change within as soon as 24 hours whereas traditional anti-depressants can take 2-4 weeks to start working. SPRAVATO® is an NMDA receptor antagonist that is believed to work differently by acting on a pathway in the brain that affects Glutamate. SPRAVATO® uses your brains most powerful natural neurotransmitter (Glutamate) to boost the reduction in depression scores faster and safer.
SPRAVATO® has been shown to:
- Provide relief of depression symptoms within as little as 24 hours
- Boost learning and memory, by clearing the depression “fog”
- Reduce brain activity associated with automatic negative thoughts (ruminations) when combined with psychotherapy
- Encourage the development of new connections in the brain when used with an approved anti-depressant
- Decrease suicidal thoughts when combined with psychotherapy
- Over time, retrain the brain to stay in this state with maintenance dosing and psychotherapy
SPRAVATO® is available only as a prescription nasal spray. Under the supervision of a certified healthcare provider, clients administer the medication themselves and are observed for a minimum of two hours to ensure there are no adverse effects.
Does SPRAVATO® Work?
Yes, SPRAVATO® has been shown to work in several studies. In one, 70 percent of patients with TRD had at least a 50 percent improvement in symptoms. Even better, over half of participants (52 to 53 percent) experienced total remission.
“In most clients, SPRAVATO® works in minutes to hours to significantly relieve symptoms. This is compelling, as antidepressants take six to 12 weeks to reach full effectiveness. Also, with antidepressants alone, up to half of people with depression fail to completely relieve their symptoms, while a third don’t receive any relief. SPRAVATO® can be a Godsend for these treatment resistant patients.”
– Justin Baksh, LMHC, BC-TMH, Chief Clinical Officer, iMind Mental Health Solutions
How Does SPRAVATO® Work?
SPRAVATO® works differently and more quickly than antidepressants. It targets the neurotransmitter glutamine, which is the most plentiful in the brain. SPRAVATO® has been shown to:
- Provide fast-acting anti-depressant effects via a rapid surge of glutamate which activates postsynaptic AMPA receptors.
- Increase brain plasticity, the ability of the brain to change and adapt by stimulating brain-derived neurotropic factor (BDNF) production and other means.
- Decrease connectivity in areas responsible for endless negative thoughts, or rumination. These include connections between dorsal and pregenual anterior consulate cortex as well as the default mode network and prefrontal cortex’s executive control network.
- Boost positive emotions and quell negative ones, by reducing overactivity in the lateral habenula, which affects the reward center. Overactivity here also leads to an inability to get the same enjoyment out of things previously enjoyed.
What is a SPRAVATO® REMS Treatment Center?
SPRAVATO® is only available at REMS (Risk Evaluation and Management) certified treatment centers, as required by the Food and Drug Administration. SPRAVATO® treatment centers must:
- Be REMS certified to receive, dispense, and treat patients with Spravato
- Ensure REMS patient enrollment with SPRAVATO® prescriber
- Directly observe and monitor patients being treated with Spravato for at least two hours
- Report to the SPRAVATO® manufacturer REMS program on a timely basis
iMind Mental Health Solutions is the first certified SPRAVATO® REMS treatment center in Port St. Lucie, Florida.
SPRAVATO®is making a real difference in the lives of people living with depression:
“When I was fully in my throes of depression, I would start every day off at a negative six or seven. After I started taking SPRAVATO® , I’m starting the day waking up neutral, which is best. My mom is my best friend… I’m actually finishing off my first semester… [and] I am learning so much stuff and growing as a person. I’m almost 24, and I never thought I’d live to see [it]. I just have so many opportunities. It’s awesome.”
– Nicole
SPRAVATO® is making a real difference in the lives of people living with treatment-resistant depression:
“When I was fully in my throes of depression, I would start every day off at a negative six or seven. After I started taking SPRAVATO® , I’m starting the day waking up neutral, which is best. My mom is my best friend… I’m actually finishing off my first semester… [and] I am learning so much stuff and growing as a person. I’m almost 24, and I never thought I’d live to see 24. I just have so many opportunities. It’s awesome.”
– Nicole
It only takes a minute to get started on the road to good mental health. We have immediate availability… contact us now!
Does Insurance Cover SPRAVATO®?
After the FDA granted approval for SPRAVATO® for treatment of treatment resistant depression in 2019, health insurance companies began to add it to their formularies. Now, SPRAVATO® is also indicated in the treatment of Major Depressive Disorder with suicidal ideation.
Prior to receiving treatment, iMind will evaluate SPRAVATO® treatment appropriateness for each client, as well as verify insurance benefits to ensure coverage and obtain prior authorization. We also accept credit cards or HSA payments for any co-pays or deductibles due.
For those without mental health benefits, we offer low cash pay rates and sliding scale fees.
- Dutta, S. (2021, March 9). What are NMDA receptors? News-Medical.net.
- Fava, M., & Davidson, K. G. (1996, June 19). Definition and epidemiology of treatment resistant depression. PubMed.
- Grieve, S., Korgaonkar, M., Koslow, S., Gordon, E., & Williams, L. (2013, August 29). Widespread Reductions in Grey Matter Volume in Depression. Science Direct.
- Healthy Place Mental Health. (2019, March 16). What is Spravato? New Drug for Treatment Resistant Depression. YouTube.
- Kang, M., Noh, J., & Chung, J. (2020, September 24). NMDA receptor-dependent long-term depression in the lateral habenula: Implications in physiology and depression. PubMed Central (PMC).
- Rege, S. (2022, October 5). Intranasal esketamine – Psychopharmacology and clinical application. Psych Scene Hub.
- Uncredited. (2022, October 4). REMS-Certified Spravato Treatment Center. SPRAVATO® (esketamine). Spravato Treatment Center.
- Webster, J. F., Lecca, S., & Wozny, C. (2021, November 26). Inhibition within the lateral Habenula—Implications for affective disorders. Frontiers.
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