Spravato Therapy at iMind

Now there is new hope for people living with depression.

  • Spravato® (esketamine) is the first and only prescription nasal spray for depression
  • FDA approved for Treatment Resistant Depression (TRD) and Major Depressive Disorder (MDD) with suicidal ideation
  • iMind is proud to be a Spravato REMS treatment center
  • We are the first in Port St. Lucie, Florida, to offer this breakthrough treatment

What is Spravato (esketamine)?

Spravato is a purified and more potent form of ketamine, without its sedative effects. Spravato has been shown to:

  • Provide immediate relief of depression symptoms
  • Boost learning and memory
  • Reduce brain activity associated with automatic negative thoughts (ruminations)
  • Encourage the development of new connections in the brain
  • Decrease suicidal thoughts
  • Over time, retrain the brain to stay in this state

Spravato is available only as a prescription nasal spray. Under the supervision of a certified healthcare provider, clients administer the medication themselves and are observed for a minimum of two hours to ensure there are no adverse effects. 

pravato Logo and Nasal Spray Bottle - No Border
Woman with hands behind head, eyes closed and leaning back, relaxing, Spravato treatment, Port St Lucie, Florida

Does Spravato Work?

Yes, Spravato has been shown to work in several studies. In one, 70 percent of patients with TRD had at least a 50 percent improvement in symptoms. Even better, over half of participants (52 to 53 percent) experienced total remission.

In most clients, Spravato works in minutes to hours to significantly relieve symptoms. This is compelling, as antidepressants take six to 12 weeks to reach full effectiveness. Also, with antidepressants alone, up to half of people with depression fail to completely relieve their symptoms, while a third don’t receive any relief. Spravato can be a Godsend for these treatment resistant patients.”

– Justin Baksh, LMHC, BC-TMH, Chief Clinical Officer, iMind Mental Health Solutions

How Does Spravato Work?

SPRAVATO works differently and more quickly than antidepressants. It targets the neurotransmitter glutamine, which is the most plentiful in the brain. Spravato has been shown to:

  • Provide fast-acting anti-depressant effects via a rapid surge of glutamate which activates postsynaptic AMPA receptors.
  • Increase brain plasticity, the ability of the brain to change and adapt by stimulating brain-derived neurotropic factor (BDNF) production and other means.
  • Decrease connectivity in areas responsible for endless negative thoughts, or rumination. These include connections between dorsal and pregenual anterior consulate cortex as well as the default mode network and prefrontal cortex’s executive control network.
  • Boost positive emotions and quell negative ones, by reducing overactivity in the lateral habenula, which affects the reward center. Overactivity here also leads to an inability to get the same enjoyment out or things previously enjoyed.

What is a Spravato REMS Treatment Center?

Spravato is only available at REMS (Risk Evaluation and Management) certified treatment centers, as required by the Food and Drug Administration. Spravato treatment centers must:

  • Be REMS certified to receive, dispense, and treat patients with Spravato
  • Ensure REMS patient enrollment with Spravato prescriber
  • Directly observe and monitor patients being treated with Spravato for at least two hours
  • Report to the Spravato manufacturer REMS program on a timely basis

iMind Mental Health Solutions is the first certified Spravato REMS treatment center in Port St. Lucie, Florida.

Patient with thumbs up and a group of doctors

Spravato is making a real difference in the lives of people living with depression:

“When I was fully in my throes of depression, I would start every day off at a negative six or seven. After I started taking Spravato, I’m starting the day waking up neutral, which is best. My mom is my best friend… I’m actually finishing off my first semester… [and] I am learning so much stuff and growing as a person. I’m almost 24, and I never thought I’d live to see [it]. I just have so many opportunities. It’s awesome.”

Nicole

Spravato is making a real difference in the lives of people living with treatment-resistant depression:

When I was fully in my throes of depression, I would start every day off at a negative six or seven. After I started taking SPRAVATO, I’m starting the day waking up neutral, which is best. My mom is my best friend… I’m actually finishing off my first semester… [and] I am learning so much stuff and growing as a person. I’m almost 24, and I never thought I’d live to see 24. I just have so many opportunities. It’s awesome.”

– Nicole

It only takes a minute to get started on the road to good mental health. We have immediate availability… contact us now!

Does Insurance Cover Spravato?

After the FDA granted approval for Spravato for treatment of treatment resistant depression in 2019, health insurance companies began to add it to their formularies. Now, Spravato is also indicated in the treatment of Major Depressive Disorder with suicidal ideation.

Prior to receiving treatment, iMind will evaluate Spravato treatment appropriateness for each client, as well as verify insurance benefits to ensure coverage and obtain prior authorization. We also accept credit cards or HSA payments for any co-pays or deductibles due.

For those without mental health benefits, we offer low cash pay rates and sliding scale fees.

Neurofeedback

How Do I Get Started?

It all starts with a free consultation. Simply call our office or submit a form to have us contact you.

Once your consultation is scheduled, you will receive an invitation to our patient portal. There, you can fill out your pre-appointment paperwork.

At your appointment, we will review your history, provide a free evaluation, and determine whether Spravato would be a good fit for you.

After receiving authorization from your insurance company, your first Spravato treatment appointment will be scheduled.

Smiling receptionist at desk, therapy port st lucie, counseling port st lucie, iMind Mental Health Solutions
  • Dutta, S. (2021, March 9). What are NMDA receptors? News-Medical.net. 
  • Fava, M., & Davidson, K. G. (1996, June 19). Definition and epidemiology of treatment resistant depression. PubMed. 
  • Grieve, S., Korgaonkar, M., Koslow, S., Gordon, E., & Williams, L. (2013, August 29). Widespread Reductions in Grey Matter Volume in Depression. Science Direct.
  • Healthy Place Mental Health. (2019, March 16). What is Spravato? New Drug for Treatment Resistant Depression. YouTube.
  • Kang, M., Noh, J., & Chung, J. (2020, September 24). NMDA receptor-dependent long-term depression in the lateral habenula: Implications in physiology and depression. PubMed Central (PMC)
  • Rege, S. (2022, October 5). Intranasal esketamine – Psychopharmacology and clinical application. Psych Scene Hub
  • Uncredited. (2022, October 4). REMS-Certified Spravato Treatment Center. SPRAVATO® (esketamine). Spravato Treatment Center.
  • Webster, J. F., Lecca, S., & Wozny, C. (2021, November 26). Inhibition within the lateral Habenula—Implications for affective disorders. Frontiers.

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